Kenny Gordon Experimental and Computational Arrhythmia Laboratory Progress Update - 10/23/12
The members of the Kenny Gordon Experimental and Computational Arrythmia Laboratory are continuing to press forward to improve the understanding of what triggers cardiac arrhythmias and how we can prevent arrythmia deaths.
In our laboratory, we use two main approaches - electrophysiology experiments and computer modeling. This year we became one of the few labs in the world to perform arrythmia experiments on cardiac cells taken from human hearts (available from patients undegoing open-heart surgery.) The findings from these experiments feed into our computer models, which enable us to look beyond the single cell into virtual hearts. Because lethal cardiac arrythmias involve dynamics that initiate at the cellular level, but manifest at the whole-heart evel, such computer models are helping us to bridge the gap between the laboratory and clinical reality.
We have made a number of important findings in the past couple of years, from discovering the nature of an arrythmogenic dynamic known as subcellular alternans in cellular experiments, to illuminating the effects of cardiac disease states on the initiation and sustainability of fibrillation in organ-level computer modeling, to helping to advance our field's understanding of how to detect and terminate the arrhythmia trigger event known as alternans (which might prevent arrythmia onset.) These and other findings are featured in a number of our publications in highly regarded scientific journals. Details of all of our publications can be found on our laboratory website at www.users.med.cornell.edu/~dchristi/publications_index.html
We would like to thank the Kenny Gordon Foundation for your invaluable support of our research efforts. With your help, we have been able to make exciting progress in working to prevent and treat cardiac arrythimias.
A letter to our dear friends and contributors:
We know how many charities solicit you throughout the year. No matter how committed we all may be to the causes we support, it's still a lot of paper filling up your mailbox. As a result, KGF makes it a point to contact you only when it is absolutely necessary. This is one of those times.